Jack T Rogers Selected Research

5' Untranslated Regions (5' UTR)

10/2020	Alpha-Synuclein in Alcohol Use Disorder, Connections with Parkinson's Disease and Potential Therapeutic Role of 5' Untranslated Region-Directed Small Molecules.
1/2020	Iron-responsive-like elements and neurodegenerative ferroptosis.
1/2013	Novel 5' untranslated region directed blockers of iron-regulatory protein-1 dependent amyloid precursor protein translation: implications for down syndrome and Alzheimer's disease.
7/2009	Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases.
8/2006	A high-throughput drug screen targeted to the 5'untranslated region of Alzheimer amyloid precursor protein mRNA.
4/2005	Pilot study of the reducing effect on amyloidosis in vivo by three FDA pre-approved drugs via the Alzheimer's APP 5' untranslated region.
1/2004	FDA-preapproved drugs targeted to the translational regulation and processing of the amyloid precursor protein.
11/2002	An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript.
8/2002	Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region.

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Jack T Rogers Research Topics

Disease

32	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 08/2002
11	Parkinson Disease (Parkinson's Disease) 10/2020 - 12/2004
7	Neuroblastoma 01/2016 - 11/2002
7	Inflammation (Inflammations) 04/2013 - 08/2004
6	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 01/2004
6	Amyloid Plaque 04/2014 - 08/2004
5	Dementia (Dementias) 01/2020 - 08/2004
4	Amyloidosis 01/2020 - 04/2005
4	Stroke (Strokes) 04/2014 - 12/2004
3	Cognitive Dysfunction 01/2020 - 07/2009
3	Iron Overload 01/2019 - 01/2014
2	Lewy Body Disease (Lewy Body Dementia) 10/2020 - 01/2020
2	Down Syndrome (Down's Syndrome) 02/2019 - 01/2013
2	Hemorrhage 04/2014 - 04/2013
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 09/2008 - 12/2004
1	Alcoholism (Alcohol Abuse) 10/2020
1	Multiple System Atrophy 10/2020
1	Neurodevelopmental Disorders 10/2020
1	Mental Disorders (Mental Disorder) 01/2020
1	Mood Disorders (Mood Disorder) 01/2020
1	Neuroinflammatory Diseases 01/2019
1	Movement Disorders (Movement Disorder) 12/2018
1	Necrotizing Enterocolitis 01/2016
1	Poisoning 01/2016
1	Cerebral Hemorrhage 04/2013
1	Traumatic Brain Injuries (Traumatic Brain Injury) 04/2013
1	Neoplasms (Cancer) 01/2013
1	Neoplasm Metastasis (Metastasis) 01/2013
1	Memory Disorders (Memory Loss) 07/2012
1	Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy) 07/2012
1	Clinical Deterioration 07/2012
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2012
1	Hemochromatosis (Bronze Diabetes) 07/2009
1	Infections 05/2009
1	Atherosclerosis 01/2009
1	Coronary Disease (Coronary Heart Disease) 01/2008

Drug/Important Bio-Agent (IBA)

20	Proteins (Proteins, Gene)FDA Link 10/2020 - 11/2004
19	Amyloid (Amyloid Fibrils)IBA 02/2019 - 11/2004
18	IronIBA 01/2020 - 11/2002
9	5' Untranslated Regions (5' UTR)IBA 10/2020 - 08/2002
7	Peptides (Polypeptides)IBA 01/2019 - 08/2002
6	Messenger RNA (mRNA)IBA 01/2019 - 08/2002
6	CytokinesIBA 01/2016 - 01/2004
5	alpha-SynucleinIBA 10/2020 - 03/2009
5	Pharmaceutical PreparationsIBA 01/2020 - 08/2002
5	Amyloid beta-PeptidesIBA 04/2014 - 12/2004
4	MetalsIBA 07/2009 - 08/2004
3	RNA (Ribonucleic Acid)IBA 01/2020 - 08/2002
3	Chelating AgentsIBA 01/2016 - 11/2002
3	Ferritins (Ferritin)IBA 01/2016 - 09/2008
3	Transcription Factors (Transcription Factor)IBA 01/2016 - 12/2004
3	phenserineIBA 01/2013 - 12/2004
3	ZincIBA 09/2010 - 08/2004
2	ManganeseIBA 10/2020 - 12/2018
2	metal transporting protein 1 (ferroportin)IBA 02/2019 - 01/2016
2	InterleukinsIBA 01/2016 - 01/2013
2	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2013 - 09/2010
2	Ceruloplasmin (Ferroxidase)IBA 01/2013 - 09/2010
2	Glutamic Acid (Glutamate)FDA Link 07/2012 - 12/2004
2	VaccinesIBA 07/2009 - 08/2004
2	ElementsIBA 07/2009 - 03/2009
2	CopperIBA 12/2008 - 08/2004
2	LuciferasesIBA 08/2006 - 01/2004
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2004 - 01/2004
1	Antidepressive Agents (Antidepressants)IBA 01/2020
1	CannabidiolIBA 01/2020
1	S-Adenosylmethionine (Ademetionine)IBA 01/2020
1	Neuroprotective AgentsIBA 02/2019
1	Amyloidogenic ProteinsIBA 01/2019
1	GhrelinIBA 10/2017
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 06/2017
1	AcidsIBA 06/2017
1	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 01/2016
1	Interleukin-6 (Interleukin 6)IBA 01/2016
1	NF-kappa B (NF-kB)IBA 01/2016
1	Ferrosoferric Oxide (Magnetite)FDA Link 01/2016
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 02/2015
1	Heme Oxygenase-1IBA 04/2013
1	HemopexinIBA 04/2013
1	Heme (Haem)IBA 04/2013
1	benzimidazoleIBA 01/2013
1	JTR-009IBA 01/2013
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 07/2012
1	Glutamate Receptors (Glutamate Receptor)IBA 07/2012
1	N-Methylaspartate (NMDA)IBA 07/2012
1	Memantine (Namenda)FDA Link 07/2012
1	Protein Isoforms (Isoforms)IBA 01/2012
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2012
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2012
1	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2012
1	SynucleinsIBA 03/2011
1	ApolipoproteinsIBA 01/2010
1	Apolipoproteins E (ApoE)IBA 01/2010
1	Estrogens (Estrogen)FDA Link 05/2009
1	DNA (Deoxyribonucleic Acid)IBA 01/2009
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2009
1	Insulin (Novolin)FDA Link 01/2009
1	Glucose (Dextrose)FDA LinkGeneric 01/2009
1	Arginine (L-Arginine)FDA Link 01/2009

Therapy/Procedure

6	Therapeutics 01/2020 - 08/2002